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LABORATORIO DE FISIOLOGÍA Y GENÉTICA DE INSECTOS

Research

Our lab is interested in understanding the key factors involved in insect early segmentation, tracheogenesis and hypoxia response using mainly Rhodnius prolixus as a model organism

Enhancing comprehension of the role of Gap genes in the genetic network governing insect segmentation.

Members

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Andrés Lavore

Principal Investigator

I obtained my PhD in 2012 from the Facultad de Ciencias Naturales y Museo-Universidad Nacional de La Plata (UNLP, Argentina) in the laboratory of Dr. Rolando Rivera Pomar. In 2013, I moved to Universidad Nacional del Noroeste de la Provincia de Buenos Aires (UNNOBA), where I'm a Researcher of CONICET and Professor.

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Maria Jose Delgado

PhD Student

I am pursuing a degree in genetics at the Universidad Nacional del Noroeste de Buenos Aires. My thesis research is conducted in Dr. Lavore's Lab, focusing on the study of segmentation genes in R. prolixus. My work aims to understand the genetic mechanisms underlying body segmentation in hemipteran insects.

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Guillermina Buzetti

PhD Student

I am currently studying for a degree in Dr. Lavore's Lab, where I am investigating the physiology and tracheogenesis in insects. My research explores the development and function of the respiratory system in R. prolixus, with the goal of enhancing our understanding of insect respiratory physiology and its evolutionary implications.

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Tobias Pera

Undergraduate Student

I am pursuing a degree in genetics at the Universidad Nacional del Noroeste de Buenos Aires. I am doing my degree thesis at Dr. Lavore's Lab, using Rhodnius prolixus as a study model to optimize a gene editing technique using CRISPR-Cas9.

Publications

  • Nazar, Ada Paula; Delgado, María José; Lavore, Andrés. Empty-spiracles is maternally expressed and essential for neurodevelopment and early embryo determination in Rhodnius prolixus. (2022). Developmental Biology.  vol.490 n°. p144 - 154. issn 0012-1606.

 

  • Lavore, Andrés; Perez-Gianmarco, Lucila; Esponda-Behrens, Natalia; Palacio, Victorio; Catalano, Maria Ines; Rivera-Pomar, Rolando; Ons, Sheila. Nezara viridula (Hemiptera: Pentatomidae) transcriptomic analysis and neuropeptidomics. (2018). Scientific Reports, 8 num.1.

 

  • Martinez-Barnetche, J , Lavore, A, Beliera, M, Tellez-Sosa, J, Zumaya-Estrada, F.A., Palacio, V,  Godoy-Lozano, E, Rivera-Pomar, R and Henry Rodríguez, M. Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors. (2018). BMC Genomics 19(1):296 DOI 10.1186/s12864-018-4696-8. 

 

  • Zumaya-Estrada, F.A., Martinez-Barnetche, J , Lavore, A, Rivera-Pomar, R and Henry Rodríguez, M.Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of IMD canonical components among hemimetabolous arthropods. (2018). Parasites & Vectors. DOI 10.1186/s13071-017-2561-2

 

  • Traverso, L, Lavore, A., Sierra, I, Palacio, V, Martinez-Barnetche, V, Latorre Estívalis, J.M., Mougabure-Cueto, G, Francini, F, Lorenzo, M.G., Henry Rodríguez, M, Ons, S, and Rivera-Pomar, R.V. Comparative and functional triatomine genomics reveals reductions and expansions in insecticide resistance-related gene families. (2017). PLoS Neglected Tropical Diseases 11(2):e0005313. DOI 10.1371/journal.pntd.0005313.

 

  • Rafael D. Mesquita; Raquel J. Vionette-Amaral; Carl Lowenberger; Rolando Rivera-Pomar; Patrick Minx; John Spieth; Fernando A. Monteiro; A. Bernardo Carvalho; Francisco Panzera; Daniel Lawson; André L. Q. Torres; José M. C. Ribeiro; Marcos H. F. Sorgine; Adriana Granzotto;  Alessandra A. Guarneri; Alexandre A. Peixoto; Ana Beatriz Walter-Nun; Ana Carolina Gandara; Ana C. A. Melo; Ana Paula Salerno; Lavore A.E., Andrew Pike; et al. Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection. (2015) PNAS; Vol. 112 no. 48, 14936–14941. doi: 10.1073/pnas.1506226112.

 

  • Lavore, A., Pascual, A., Salinas, F.M., Martinez Barnetche, J., Henry Rodriguez, M. and Rivera-Pomar, R. Comparative analysis of zygotic developmental genes in Rhodnius prolixus genome shows conserved features on the tracheal developmental pathway. (2015). Insect Biochemistry and Molecular Biology, Vo 64, 32–43, doi:10.1016/j.ibmb.2015.06.012.

 

  • Ons; S.*, Lavore, A.*, Sterkel, M., Wulff, J.P., Sierra, I., Martinez Barnetche, J., Henry Rodriguez, M. and Rivera-Pomar, R. Analysis of the Rhodnius prolixus central nervous system transcriptome unveils the expression of neuropeptides and G-protein coupled receptors for opsins and neurohormones. (2015). Insect Biochemistry and Molecular Biology, doi:10.1016/j.ibmb.2015.05.003.

  • Lavore, A., Esponda-Behrens, N., Pagola, N., Rivera-Pomar, R., “Rhodnius prolixus gap gen Krüppel is required for the embryo central body region formation”.  (2014). Developmental Biology, 387.121–129.

  • Lavore A., Pagola L., Esponda-Behrens N., Rivera-Pomar R. The gap gene giant of Rhodnius prolixus is maternally expressed and required for proper head and abdomen formation. (2012). Developmental Biology. doi:10.1016/j.ydbio.2011.06.038.

Gallery

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